研究成果

  • T, Tan CT, Chang CC, Chu CY, Lee WJ, Lin BZ, Lin MT, Kuo ML.(2016) G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway. Nat Cell Biol. 18(9):993-1005. doi: 10.1038/ncb3395.
  • Lin PC, Lu CW, Shen BN, Lee GZ, Bowman JL, Arteaga-Vazquez MA, Liu LYD, Hong SF, Lo CF, Su GM, Kohchi T, Ishizaki K, Zachgo S, Althoff F, Takenaka M, Yamato KT, Lin SS*. (2016) Identification of miRNAs and their targets in the liverwort Marchantia polymorpha by integrating RNA-Seq and degradome analyses. Plant Cell Physiol. 57:339-358.
  • Chepyala SR, Chen YC, Yan CC, Lu CY, Wu YC* and Hsu CP*. (2016) Noise propagation with interlinked feed-forward pathways. Sci. Rep. 6:23607. doi: 10.1038/srep23607 
  • Hang YL, Hsieh MH, Chang WW, Wang HY, Lin MC, Wang CP, Lou PJ, Teng SC. Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. (2015) Antioxidants& Redox Signaling, 22, 587-602.
  • Hsieh MS, Tsai CH, Lin CC, Li TK, Hung TW, Chang LT, Hsin LW, Teng SC. (2015) Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers. Cellular and Molecular Life Sciences, 72: 1825-1837.
  • Kuo YC, Wu HT, Hung JJ, Chou TY, Teng SC, Wu KJ. (2015) Nijmegen breakage syndrome protein 1 (NBS1) modulates hypoxia inducible factor-1α (HIF-1α) stability and promotes in vitro migration and invasion under ionizing radiation. Int. J. Biochem. Cell Biol. 64: 229-238.
  • Hung SY, Huang WP, Liou HC, Fu WM. (2015) LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacol., 93: 243-251. (SCI)
  • Hung TM, Yuan RH, HuangWP, Chen YH, Lin YC, Lin CW, Lai HS, Lee PH. (2015) Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. Am. J. Pathol., 185: 2454-2467.
  • Lee SJ, Tsao KC, Cherng BW and Liao YH. Lysophospholipid receptor signaling in zebrafish development. Transl Cancer Res, 2015, 4: 544-556.
  • Wu BT, Wen SH, Hwang SP, Huang CJ and Kuan YS.*. Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression. (2015). J. Cell Sci. 128:2328-2339.
  • Kuan YS, Roberson S, Akitake CM, Fortuno L, Gamse JT, Moens CB, and Halpern ME. (2015). Distinct requirement for Wntless in habenular development. Dev. Biol. 406(2):117-128.
  • Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, Meng TC, Chen GC. (2015) Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation. Oncogene 34: 3791-803.
  • Lee DY and Chang GD.* (2015), Quantitative LC-ESI-MS analysis of amine-containing metabolites derivatized with cyanuric chloride and methylamine isotopologues, J. Chromatography A 1338: 60-68.
  • Yu CH, Chou CC, Lee YJ, Khoo KY, and Chang GD.* (2015) Uncovering Protein Polyamination by the Spermine-specific Antiserum and Mass Spectrometric Analysis, Amino Acids, 47, 469–481
  • Lee, DY and Chang GD*. (2015) Simultaneous Immunoblotting Analysis with Activity Gel Electrophoresis and 2-D Gel Electrophoresis, Methods Mol. Biol. 1312:61-72.
  • Lee, DY and Chang GD*. (2015) Post-staining electroblotting for reliable peptide blotting, Methods Mol. Biol. 1312:185-195.
  • Lin SJ, Lee DY, Wang HC, Kang ST, Hwang PP, Kou GH, Huang MF, Chang GD*, Lo CF*. (2015) White Spot Syndrome Virus Protein Kinase 1 (PK1) Defeats the Host Cell's Iron Withholding Defense Mechanism by Interacting with Host Ferritin. J. Virol. 89, 1083-1093.
  • Klionsky DJ, et al. "Guidelines for the use and interpretation of assays for monitoring autophagy" Autophagy (in press).
  • Hu CW, Hsu CL, Wang YC, Ishihama Y, Ku WC, Huang HC* and Juan HF.* (2015) "Temporal phosphoproteome dynamics induced by an ATP synthase inhibitor citreoviridin" Molecular & Cellular Proteomics 14(12):3284-98.
  • Hsu CL, Juan HF.*, and Huang HC.* (2015) "Characterization and functional analysis of differential coexpression networks" Scientific Reports 5:13295.
  • Jen J, Lin LL, Chen HT, Liao SY, Lo FY, Tang YA, Hsu HS, Salgia R, Hsu CL, Huang HC, Juan HF*, Wang YC.* (2015) "Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer" Oncogene (doi: 10.1038/onc.2015.296).
  • Lin LL, Hsu CL, Hu CW, Ko SY, Hsieh HL, Huang HC*, Juan HF.* (2015) "Integrating phosphoproteomics and bioinformatics to study brassinosteroid-regulated phosphorylation dynamics in Arabidopsis" BMC Genomics 16:533. (Highly accessed)
  • Lin LL, Huang HC*, Juan HF.* (2015) "Circadian systems biology in metazoa" Briefings in Bioinformatics 16(6):1008-24
  • Huang MJ, Hu RH, Chou CH, Hsu CL, Liu YW, Huang J, Hung JS, Lai IR, Juan HF, Yu SL, Wu YM.* and Huang MC.* (2015) "Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling" Oncotarget 6(8):5650-65.
  • Lee AYL*, Chiu YC, Fang WC, Cheng CW, Kuo CY, Juan HF, Wu SH* and Kao TY.* (2015) "Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex" Cell Death & Disease 6:e1642.
  • Lin LL, Hsia CR, Hsu CL, Huang HC* and Juan HF.* (2015) "Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells" BMC Genomics 16(1):41.
  • Chang HY, Li MH, Huang TC, Hsu CL, Tsai SR, Lee SC*, Huang HC* and Juan HF.* (2015) "Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells" Journal of Proteome Research 14(2):1250-62.
  • Chan CC, Fan MY, Wan WH, Lin SJ*. (2015) A two-stepped culture method for efficient production of trichogenic keratinocytes. Tissue Engineering Part C Methods 21:1070-9.
  • Lin YC, Lin MW, Yen MH, Fan SMY, Wu JT, Young TH, Cheng JY, Lin SJ*. (2015) Programmable laser-assisted surface microfabrication on a polyvinyl alcohol-coated glass chip with self-changing cell adhesivity for heterotypic cell patterning. ACS Applied Materials& Interfaces 7:22322-32.
  • Chen KL, Chiu HY, Chan CC, Chan JY, Lin SJ*. Extensive cicatricial alopecia in a patient with long-term trichotillomania. Journal of Dermatology (accepted).
  • Wu YF, Wang SH, Wu PS, Sabrina Fan MY, Chiu HY, Tsai TH, Lin SJ*. (2015) Enhancing hair follicle regeneration by nonablative fractional laser: assessment of irradiation parameters and tissue response. Lasers in Surgery and Medicine 47:331-41.
  • Chiu HY, Wang TS, Chan CC, Lin SJ, Tsai TF. Risk factor analysis for the immunogenicity of adalimumab associated with decreased clinical response in Chinese patients with psoriasis. Acta Dermato-Venereologica 95:71-6, 2015.
  • Sheen YS, Fan SMY, Chan CC, Wu YF, Jee SH, Lin SJ*. Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro. Lasers in Surgery and Medicine 47: 50-9, 2015.
  • Chiu HY, Huang HL, Li CH, Yin YJ, Chen HA, Hsu ST, Lin SJ, Tsai TF, Ho SY. Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study. British Journal of Dermatology 173:146-54, 2015.
  • Oh JW, Lin SJ, Plikus MV. Regenerative metamorphosis in hairs and feathers: follicle as a programmable biological printer. Experimental Dermatology 24:262-4, 2015.
  • Lin KH, Liao BY, Chang HW, Huang SW, Chang TY, Yang CY, Wang YB, Kirk Lin YT, Wu YW, Tang SL and Yu HT Metabolic characteristics of dominant microbes and key rare species from an acidic hot spring in Taiwan revealed by metagenomics. BMC Genomics 2015, 16:1029
  • Wada K, Lee JY, Hung HY, Shi Q, Lin L, Zhao Y, Goto M, Yang PC, Kuo SC, Chen HW*, Lee KH*. Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects. Bioorg Med Chem. 2015 Apr 1;23(7):1507-14.
  • Huang CH, Tsai MS, Chiang CY, Su YJ, Wang TD, Chang WT, Chen HW, Chen WJ. Activation of mitochondrial STAT-3 and reduced mitochondria damage during hypothermia treatment for post-cardiac arrest myocardial dysfunction. Basic Res Cardiol. 2015 Nov;110(6):59.
  • Yuan A, Hsiao YJ, Chen HY, Chen HW, Ho CC, Chen YY, Liu YC, Hong TH, Yu SL, Chen JJ, Yang PC. Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression. Sci Rep. 2015, 5:14273.
  • Lai YH, Chen MH, Lin SY, Lin SY, Wong YH, Yu SL, Chen HW, Yang CH, Chang GC, Chen JJ. Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways. Oncotarget. 2015 Sep 22;6(28):26252-65.
  • Tsai MS, Huang CH, Yu PH, Tsai CY, Chen HW, Cheng HJ, Chang WT, Wang TD, Chen WJ. Prolonged cooling duration mitigates myocardial and cerebral damage in cardiac arrest. Am J Emerg Med. 2015 Oct;33(10):1374-81.
  • Liao HY, Chen JH, Shyue JJ, Shun CT, Chen HW, Liao SW, Hong CK, Chen PS. Rapid label-free determination of ketamine in whole blood using secondary ion mass spectrometry. Talanta. 2015 Oct 1;143:50-5.
  • Chen HY, Yu SL, Ho BC, Su KY, Hsu YC, Chang CS, Li YC, Yang SY, Hsu PY, Ho H, Chang YH, Chen CY, Yang HI, Hsu CP, Yang TY, Chen KC, Hsu KH, Tseng JS, Hsia JY, Chuang CY, Yuan S, Lee MH, Liu CH, Wu GI, Hsiung CA, Chen YM, Wang CL, Huang MS, Yu CJ, Chen KY, Tsai YH, Su WC, Chen HW, Chen JJ, Chen CJ, Chang GC, Yang PC, Li KC. R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability. J Clin Oncol. 2015, 33(20):2303-10.
  • Huang CH, Chiang CY, Pen RH, Tsai MS, Chen HW, Hsu CY, Wang TD, Ma MH, Chen SC, Chen WJ. Hypothermia treatment preserves mitochondrial integrity and viability of cardiomyocytes after ischaemic reperfusion injury. Injury. 2015, 46(2):233-9.
  • Bowman, J.L., Araki, T., Arteaga-Vazquez, M.A., Berger, F., Dolan, L., Haseloff, J., Ishizaki, K., Kyozuka, J., Lin, S.S., Nagasaki, H., Nakagami, H., Nakajima, K., Nakamura, Y., Ohashi-Ito, K., Sawa, S., Shimamura, M., Solano, R., Tsukaya, H., Ueda, T., Watanabe, Y., Yamato, K.T., Zachgo, S., Kohchi, T. 2015. The naming of names: guidelines for gene nomenclature in Marchantia. Plant Cell Physiol. (Accepted)
  • Chen KI, Pan CY, Li KH, Huang YC, Lu CW, Tang CY, Su YW,Tseng LW, Tseng KC, Lin CY, Chen CD, Lin SS*, Chen YT*. 2015. Isolation and identification of post-transcriptional gene silencing-related micro-RNAs by functionalized silicon nanowire field-effect transistor. Sci. Rep. 5, 17375
  • Liu CT, Huang HM, Hong SF, Kuo-Huang LL, Yang CY, Lin YY, Lin CP*, Lin SS.* 2015. Peanut witches’ broom (PnWB) phytoplasma-mediated leafy flower symptoms and abnormal vascular bundles development. Plant Signal Behav. (Accepted)
  • Lee CT, Chen IT, Yang YT, Ko TP, Huang YT, Huang JY, Huang MF, Lin SJ, Chen CY, Lin SS, Lightener DV, Wang HC, Wang AHJ, Wang HC, Hor LI, Lo CF. 2015. The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin. PNAS 112:10798-10803.
  • Liao HF, Mo CF, Wu SC, Cheng DH, Yu CY, Chang KW, Kao TH, Lu CW, Pinskaya M, Morillon A, Lin SS, Cheng WT, Bourc'his D, Bestor T, Sung LY, Lin SP. 2015. Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. Reproduction 150:245-256.
  • Yang CY, Huang YH, Lin CP, Lin YY, Hsu HC, Wang CN, Liu LY, Shen BN, Lin SS.* 2015. MiR396-targeted SHORT VEGETATIVE PHASE is required to repress flowering and is related to the development of abnormal flower symptoms by the Phyllody Symptoms1 effector. Plant Physiol. 168:1702-1716.
  • Hu SF, Huang YH, Lin, C.P., Liu, L.Y.D., Hong, S.F., Yang, C.Y., Lo, H.F., Tseng, T.Y., Chen, W.Y., Lin, S.S.* 2015. Development of a mild viral expression system for gain-of-function study of phytoplasma effector in planta. PLOS ONE. 10:e0130139
  • Huang CH, Hsiao WR, Huang CW, Chen KC, Lin SS, Chen TC, Raja JAJ, Wu HW, Yeh SD. 2015. Two novel motifs of Watermelon silver mottle virus NSs protein are responsible for RNA silencing suppression and pathogenicity. PLOS ONE. 10:e0126161
  • Lin YL, Ma LT, Lee YR, Lin SS, Wang SY, Chang TT, Shaw JF, Li WH, Chu FF. 2015. MicroRNA-like small RNAs prediction in the development of Antrodia cinnamomea. PLOS ONE. 10:e0123245
  • Lin PC, Hu WC, Lee SC, Chen YL, Lee CY, Chen YR, Liu LYD, Chen PY., Lin SS.*, Chang YC.* 2015. Application of an integrated omics approach for identifying host proteins that interact with Odontoglossum ringspot virus capsid protein. Mol. Plant Microbe Interact. 28:711-726
  • Yang HW, He BZ, Ma HJ, Tsaur SC, Ma CY, Wu Y, Ting CT, Zhang YE* (2015) Expression profile and gene age jointly shaped the genome-wide distribution of premature termination codons in Drosophila populations. Molecular Biology and Evolution. 32: 216-228. (IF= 13.649 in 2015)
  • Chen WY, Shih HT, Liu KY, Shih ZS, Chen LK, Tsai TH, Chen MJ, Liu H, Tan BCM, Chen CY, Lee HH, Loppin B, Ait-Ahmed O, Wu JT*(2015) Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. EMBO Reports 16:528-538. (IF= 7.739 in 2015)
  • Sheen YS, Liao YH, Lin MH, Chu CY, Ho BY, Hsieh MC, Chen PC, Cha ST, Jeng YM, Chang CC, Chiu HC, Jee SH, Kuo ML, Chu CY* (2015) IMP-3 promotes tumor invasion and predicts poor prognosis in melanoma by regulating HMGA2 expression. J. Invest. Dermatol. 135(4):1065-1073. (IF= 6.915 in 2015)
  • Yi YH, Ma TH, Lee LW, Chiou PT, Chen PH, Lee CM, Chu YD, Yu H, Hsiung KC, Tsai YT, Lee CC, Chang YS, Chan SP*, Tan BC*, Lo SJ.* (2015) A genetic cascade of let-7-ncl-1-fib-1 modulates nucleolar size and rRNA pool in Caenorhabditis elegans. PLoS Genet. 11(10):e1005580.
  • Chen YC, Chiang HH, Cho YT, Chang CY, Chen KL, Yang CW, Lee YH, Chu CY* (2015) Human herpes virus reactivations and dynamic cytokine profiles in patients with cutaneous adverse drug reactions—a prospective comparative study. Allergy 70(5):568-575. (IF= 6.335 in 2015)
  • Chang CF, Chu PC, Wu PY, Yu MY, Lee JY, Tsai MD, Chang MS* (2015) PHRF1 promotes genome integrity by modulating non-homologous end-joining. Cell Death Dis. 6:e1716. (IF= 5.378 in 2015)
  • Chang YY, Hsu CH*(2015) Structural basis for substrate-specific acetylation of Nalpha-acetyltransferase Ard1 from Sulfolobus solfataricus. Sci. Rep. 5:8673-8681. (IF= 5.228 in2015)
  • Chen KI, Pan CY, Li KH, Huang YC, Lu CW, Tang CY, Su YW,Tseng LW, Tseng KC, Lin CY, Chen CD, Lin SS*, Chen YT*(2015) Isolation and identification of post-transcriptional gene silencing-related microRNAs by functionalized silicon nanowire field-effect transistor. Sci. Rep. 5:17575-17584 (IF= 5.228 in 2015)
  • Lin IC, Yang HC, Strong C, Yang CW, Cho YT, Chen KL, Chu CY* (2015) Liver injury in drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical study of 72 cases. J. Am. Acad. Dermatol. 72(6):984-991. (IF= 5.621 in 2015)
  • Chang KW, Huang NA, Liu IH, Wang YH, Wu P, Tseng YT, Hughes MW, Jiang TX, Tsai MH, Chen CY, Oyang YJ, Lin EC*, Chuong CM*, Lin SP*. 2015. Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin. BMC Genomics.16:22.
  • Chen WJ, Ho CC, Chang YL, Chen HY, Lin CA, Lin TY, Yu SL, Yuan SS, Chen YL, Lin CY, Pan SH, Chou HYE, Chen YJ, Chang GC, Chu WC, Lee YM, Lee JY, Lee PJ, Li KC, Chen HW*, Yang PC*. Cancer-Associated Fibroblasts Regulate the Plasticity of Lung Cancer Stemness via Paracrine Signalling. Nature Comm., 2014, 5:3472. *Corresponding author.
  • Yang DK, Chen LC*, Lee MY, Hsu CH, Chen CS. (2014) Selection of aptamers for fluorescent detection of alpha-methylacyl-CoA racemase by single-bead SELEX. Biosens. Bioelectron. 62:106-112. (IF= 7.476 in 2015)
  • Lu KY, Lin CW, Hsu CH, Ho YC, Chuang EY, Sung HW*, Mi FL* (2014) FRET-based dual-emission and pH-responsive nanocarriers for enhanced delivery of protein across intestinal epithelial cell barrier. ACS Appl. Mater. Interfaces 6:18275-18289. (IF= 7.145 in 2015)
  • Su MA, Huang YT, Chen IT, Lee DY, Hsieh YC, Li CY, Ng TH, Liang SY, Lin SY, Huang SW, Chiang YA, Yu HT, Khoo KH, Chang GD, Lo CF, Wang HC (2014). An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLoS Pathogens. 10:e1004196. (IF= 7.003 in 2015)
  • Jiang HS, Wu YC*. (2014) LIN-3/EGF promotes the programmed cell death of specific cells death in Caenorhabditis elegans by transcriptional activation of the pro-apoptotic gene egl-1. PLoS Genet. 10(8): e1004513. (IF= 6.661 in 2015)
  • Yoshizawa G, Ho CW, Zhu W, Hu C, Syukriani Y, Lee I, Kim H, Tsai DFC, Minari1Jand Kato K. (2014) ELSI practices in genomic research in East Asia: implications for research collaboration and public participation. Genome Medicine 6:39. (IF= 5.700 in 2015)
  • Cheng JCC, Yen WJ, Chang WT, Wu KCC, Ko MC, Li CY. (2014) Risk of adolescent offspring’s completed suicide increases with the history of their same-sex parent’s death by suicide. Psychol. Med. 44: 1845-1854. (IF= 5.491 in 2015)
  • Lu TP, Hsu YY, Lai LC, Tsai MH, Chuang EY. (2014) Identification of gene expression biomarkers for predicting radiation exposure. Sci. Rep. 4:6293-6299. (IF= 5.228 in 2015)
  • Liu LY, Tseng HI, Lin CP, Lin YY, Huang YH, Huang CK, Chang TH, Lin SS*. 2014. High-throughput transcriptome analysis of the leafy flower transition of Catharanthus roseus induced by peanut witches’-broom phytoplasma infection. Plant Cell Physiol. 55:942-957. (17/209 in Plant Sciences)
  • Kao L, Wang YT, Chen YC, Tseng SF, Jhang JC, Chen YJ, Teng SC. Global analysis of Cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis. (2014) Mol Cell Proteomics. 13, 594-605.
  • Huang YL, Chang CL, Tang CH, Lin YC, Ju TK, Huang WP *, and Lee H. * Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. Cell. Signal., 26: 611-618. (2014)
  • Tung YT, Wang BJ, Hsu WM, Hu MK, Her GM, Huang WP, and Liao YF.* Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation. Mol. Neurobiol., 49: 10-27. (2014)