研究成果

  • Chiu YC, Hsu TS, Huang CY, Hsu CH*. (2021) Structural and biochemical insights into a hyperthermostable urate oxidase from Thermobispora bispora for hyperuricemia and gout therapy. Int J Biol Macromol. 188:914-23.
  • Chiu YC, Tseng MC, Hsu CH*. (2021) Expanding the substrate specificity of macro domains toward 3″-isomer of O-acetyl-ADP-ribose. ACS Catal. 11(17):11075–90.
  • Li A, Huang HT, Huang HC*, Juan HF*. (2021) LncTx: A network-based method to repurpose drugs acting on the survival-related lncRNAs in lung cancer. Comput Struct Biotechnol J. 19:3990-4002.
  • Lee TT, Chen PL, Su MP, Li JC, Chang YW, Liu RW, Juan HF, Yang JM, Chan SP, Tsai YC, von Stockum S, Ziviani E, Kamikouchi A, Wang HD, Chen CH*. (2021) Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila. Aging Cell 20(6):e13379.
  • Wang WH, Chen SK, Huang HC*, Juan HF*. (2021) Proteomic analysis reveals metformin suppresses PSMD2, STIP1 and CAP1 for anti-gastric cancer AGS cell proliferation and migration. ACS Omega 6(22):14208-19.
  • Hsu CL†, Ou DL†, Bai LY, Chen CW, Lin L, Huang SF, Cheng AL, Cheng YM*, Hsu C*. (2021) Exploring markers of exhausted CD8 T cells to predict response to immune checkpoint inhibitor therapy for hepatocellular carcinoma. Liver Cancer 10(4):346-59.
  • Wang MH†, Hsu CL†, Wu CH, Chiou LL, Tsai YT, Lee HS*, Lin SP*. (2021) Timing does matter: Nerve-mediated HDAC1 paces the temporal expression of morphogenic genes during axolotl limb regeneration. Front Cell Dev Biol. 9:641987.
  • Ou DL, Tseng SJ, Kempson IM, Hsu CL, Yang PC, Liao ZX*. (2021) Enhanced targeting and immune activation of tumor microenvironment by nanomodified anti-PD1 in liver cancer. Adv Therapeutics. 4(6):2100048.
  • Ou DL†, Chen CW†, Hsu CL†, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH*, Hsu C*. (2021) Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer. 9(3):e001657.
  • Peng C, Li YH. Yu CW, Cheng ZH, Liu JR, Hsu JL, Hsin LW, Huang CT, Juan HF, Chern JW, Cheng YS*. (2021) Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg Chem. 110:104813.
  • Lin MH, Cho CC, Chiu YC, Chien CY, Huang YP, Chang CF, Hsu CH*. (2021) Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites. Commun Biol. 4(1):123.
  • He MY, Lin YJ, Kao YL, Kuo P, Grauffel C, Lim C, Cheng YS, Chou HHD*. (2021) Sensitive and specific cadmium biosensor developed by reconfiguring metal transport and leveraging natural gene repositories. ACS Sens. 6(3): 995-1002.
  • Chen TF, Chang YC, Hsiao Y, Lee KH, Hsiao YC, Lin YH, Tu YCE, Huang HC, Chen CY*, Juan HF*. (2021) DockCoV2: a drug database against SARS-CoV-2. Nucleic Acids Res. 49(D1):D1152-59.
  • Chiang CS, Fu SJ, Hsu CL, Jeng CJ, Tang CY, Huang YS, Tang SC*. (2021) Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed miRNAs and affecting neuronal survival and neurite outgrowth. Neuromolecular Med. 23(3):404-15.
  • Wen JD, Kuo ST, Chou HHD*. (2020) The diversity of Shine-Dalgarno sequences sheds light on the evolution of translation initiation. RNA Biol. DOI: 10.1080/15476286.2020.1861406.
  • Huang CT, Chao TL, Kao HC, Pang YH, Lee WH, Hsieh CH, Chang SY*, Huang HC*, Juan HF*. (2020) Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19. Heliyon 6(12):e05646 (Cell Press).
  • Hung SY, Lin CC, Hsu CL, Yao CY, Wang YH, Tsai CH, Hou HA, Chou WC*, Tien HF*. (2021) The expression levels of long non‐coding RNA KIAA0125 are associated with distinct clinical and biological features in myelodysplastic syndromes. Br J Haematol. 192(3):589-98.
  • Wang YH, Lin CC, Hsu CL, Hung SY, Yao CY, Lee SH, Tsai CH, Hou HA, Chou WC*, Tien HF*. (2021) Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125. Ann Hematol. 100(2):487-98.
  • Chung KP, Huang YL, Chen YJ, Juan YH, Hsu CL, Nakahira K, Huang YT, Lin MW, Wu SG, Shih JY, Chang YL, Yu CJ*. (2021) Multi-kinase framework regulates activation of dynamin-related protein 1 to promote proliferation and invasion of lung adenocarcinoma. Mol Oncol. 15(2):560-78.
  • Lin MH, Chang SC, Chiu YC, Jiang Bc, Wu TH, Hsu CH*. (2020) Structural, biophysical, and biochemical elucidation of the SARS-CoV-2 nonstructural protein 3 macro domain. ACS Infect Dis. 6(11):2970-78.
  • Wu AYT, Sung YC, Chen YJ, Chou STY, Guo V, Chien JCY, Ko JJS, Yang AL, Huang HC, Chuang JC, Wu S, Ho MR, Ericsson M, Lin WW, Cheung CHY, Juan HF, Ueda K, Chen Y, Lai C PK*. (2020) Multi-resolution imaging using bioluminescence resonance energy transfer identifies distinct biodistribution profiles of extracellular vesicles and exomeres with redirected tropism. Adv Sci. 7(19):2001467.
  • Chang YW, Hsu CL, Tang CW, Chen XJ, Huang HC*, Juan HF*. (2020) Multiomics reveals ectopic ATP synthase blockade induces cancer cell death via a lncRNA-mediated phospho-signaling network. Mol Cell Proteomics 19(11):1805-25.
  • Chang YY, Hagawa S, Hsu CH*. (2020) Adaptation of thermophilic acetyltransferase to a water-mediated catalytic mechanism. Chem Commun. 56(72):10537-40.
  • Wang HY, Liu YN, Wu SG, Hsu CL, Chang TH, Tsai MF, Lin YT, Shih JY*. (2020) MiR-200c-3p suppression is associated with development of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer via a mediating epithelial-to-mesenchymal transition (EMT) process. Cancer Biomark. 28(3):351-63.
  • Cheung HYC, Hsu CL, Lin TY, Chen WT, Wang YC, Huang HC*, Juan HF*. (2020) ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. J Biomed Sci. 27(1):75.
  • Wang WH, Hsu CL, Huang HC*, Juan HF*. (2020) Quantitative phosphoproteomics reveals cell alignment and mitochondrial length change under cyclic stretching in lung cells. Int J Mol Sci. 21(11):4074.
  • Kuo ST, Jahn RL, Cheng YJ, Chen YL, Lee YJ, Hollfelder F, Wen JD, Chou HHD*. (2020) Global fitness landscapes of the Shine-Dalgarno sequence. Genome Res. 30(5): 711-23.
  • Chen SC, Wu SP, Chang YY, Hwang TS, Lee* TH, Hsu CH*. (2020) Crystal structure of α-galactosidase from Thermus thermophilus: Insight into hexamer assembly and substrate specificity. J Agric Food Chem. 68(22):6161-69.
  • Yin CF, Kao SC, Hsu CL, Cheung CHY, Chang YW, Huang HC*, Juan HF*. (2020) Phosphoproteome analysis reveals dynamic heat shock protein 27 phosphorylation in tanshinone IIA-induced cell death. J Proteome Res. 19(4):1620-34.
  • Ho TC, Wang EY, Yeh KH, Jeng YM, Horng JH, Wu LL, Chen YT, Huang HC, Hsu CL, Chen PJ, Yeh SH*, Chen DS*. (2020) Complement C1q mediates the expansion of periportal hepatic progenitor cells in senescence-associated inflammatory liver. PNAS. (2020) 117(12):6717-25.
  • Shen YC, Hsu CL, Jeng YM, Ho MC, Ho CM, Yeh CP, Yeh CY, Hsu MC, Hu RH, Cheng AL*. (2020) Reliability of a single-region tumor sample for evaluating the immune tumor microenvironment of hepatocellular carcinoma tumors. J Hepatol. 72(3):489-97.
  • Wang YH, Lin CC, Yao CY, Hsu CL, Hou HA, Tsai HC, Chou WC*, Tien HF*. (2020) A four-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients. Blood Adv. 4(4):644-54.
  • Lee PC, Chen ST, Kuo TC, Lin TC, Lin MC, Huang J, Hung JS, Hsu CL, Juan HF, Lee PH, Huang MC*. (2020) C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene 39(13):2724-40.
  • Chang HC, Huang HC, Juan HF*, Hsu CL*. (2019) Investigating the role of super-enhancer RNAs underlying embryonic stem cell differentiation. BMC Genomics 20(Suppl 10):896.
  • Lee WH, Chen KP, Wang K, Huang HC*, Juan HF*. (2020) Characterizing the cancer-associated microbiome with small RNA sequencing data. Biochem Biophys Res Commun. 522(3):776-82.
  • Wu PY, Yu IS, Lin YC, Chang YT, Chen CC, Lin KH, Tseng TH, Kargren M, Tai YL, Shen TL, Liu YL, Wang BJ, Chang CH, Chen WM, Juan HF, Huang SF, Chan YY, Liao YF, Hsu WM*, Lee H*. (2019) Activation of aryl hydrocarbon receptor by kynurenine impairs progression and metastasis of neuroblastoma. Cancer Res. 79(21):5550-62.
  • Cheung HYC, Hsu CL, Tsuei CY, Kuo TT, Huang CT, Hsu WM, Chung YH, Wu HY, Hsu CC, Huang HC*, Juan HF*. (2019) Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy. Cell Death Dis. 10(11):786.
  • Hsieh CH, Cheung CHY, Liu YL, Hou CL, Hsu CL, Huang CT, Yang TS, Chen SF, Chen CN, Hsu WM*, Huang HC*, Juan HF*. (2019) Quantitative proteomics of Th-MYCN transgenic mice reveals aurora kinase inhibitor altered metabolic pathways and enhanced ACADM to suppress neuroblastoma progression. J Proteome Res. 18(11):3850-66.
  • Huang CT, Hsieh CH, Lee WC, Liu YL, Yang TS, Hsu WM, Oyang YJ, Huang HC*, Juan HF*. (2019) Therapeutic targeting of non-oncogene dependencies in high-risk neuroblastoma. Clin Cancer Res. 25(13):4063-78.
  • Cho CC, Chien CY, Chiu YC, Lin MH, Hsu CH*. (2019) Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans. Nat Commun. 10(1):1491.
  • Huang CT, Hsieh CH, Chung YH, Oyang YJ, Huang HC*, Juan HF*. (2019) Perturbational gene-expression signatures for combinatorial drug discovery. iScience 15:291-306 (Cell Press).
  • Yang TW, Sahu D, Chang YW, Hsu CL, Hsieh CH, Huang HC*, Juan HF*. (2019) RNA-binding proteomics reveals MATR3 interacting with lncRNA SNHG1 to enhance neuroblastoma progression. J Proteome Res. 18(1):406-16.
  • Chang JY, Yu WH, Juan HF*, Huang HC*. (2018) Dynamics of alternative polyadenylation in human preimplantation embryos. Biochem Biophys Res Commun. 504(4):727-33.
  • Huang CT, Hsieh CH, Oyang YJ, Huang HC*, Juan HF*. (2018) A large-scale gene expression intensity-based similarity metric for drug repositioning. iScience 7: 40-52. (Cell Press)
  • Lin MC, Chien PH, Wu HY, Chen ST, Juan HF, Lou PJ*, Huang MC*. (2018) C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer. Oncogene 37(43):5780-93.
  • Sahu D, Ho SY, Juan HF*, Huang HC*. (2018) High-risk, expression-based prognostic long noncoding RNA signature in neuroblastoma. JNCI Cancer Spectr. 2(2):pky015.
  • Cheng AN, Fan CC, Lo YK, Kuo CL, Wang HC, Lien IH, Lin SY, Chen CH, Jiang SS, Chang IS, Juan HF, Lyu PC, Lee AYL* (2017) Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. Sci Rep. 7(1):17024.
  • Cheung HYC, Hsu CL, Chen KP, Chong ST, Huang HC*, Juan HF*. (2017) MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach. Sci Rep. 7(1):13302.
  • Hsu CL, Wang JK, Lu PC, Huang HC*, Juan HF*. (2017) DynaPho: a web platform for inferring the dynamics of time-series phosphoproteomics. Bioinformatics 33(22):3664-66.
  • Hua KT, Liu YF, Hsu CL, Cheng TY, Yang CY, Chang JS, Lee WJ, Hsiao M, Juan HF, Chien MH*, Yang SF*. (2017) 3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma. Sci Rep. 7(1):4466.
  • Cheung CHY, Juan HF*. (2017) Quantitative Proteomics in Lung Cancer. J Biomed Sci. 224(1):37
  • Liao SY, Chiang CW, Hsu CH, Jen J, Juan HF, Lai WW, Wang YC*. (2017) CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression. Oncogene 36(41):5722-33.
  • Lin TC, Chen ST, Huang MC, Huang J, Hsu CL, Juan HF, Lin HH, Chen CH*. (2017) GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity. Oncotarget 8(26):42588-601.
  • Lin MC, Lin JJ, Hsu CL, Juan HF, Lou PJ*, Huang MC*. (2017) GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness. Oncogene 36(30):4243-52.
  • Chang HH, Liu YL, Lu MY, Jou ST, Yang YL, Lin DT, Lin KH, Tzen KY, Yen RF, Lu CC, Liu CJ, Peng S SF, Jeng YM, Huang SF, Lee H, Juan HF, Huang MC, Liao YF, Lee YL*, Hsu WM*. (2017) A multidisciplinary team care approach to improving outcomes in pediatric patients with high-risk neuroblastoma. Oncotarget 8(3):4360-72.
  • Chepyala SR, Chen YC, Yan CC, Lu CY, Wu YC* and Hsu CP*. (2016) Noise propagation with interlinked feed-forward pathways. Sci. Rep. 6:23607. doi: 10.1038/srep23607 
  • Hang YL, Hsieh MH, Chang WW, Wang HY, Lin MC, Wang CP, Lou PJ, Teng SC. Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. (2015) Antioxidants& Redox Signaling, 22, 587-602.
  • Hsieh MS, Tsai CH, Lin CC, Li TK, Hung TW, Chang LT, Hsin LW, Teng SC. (2015) Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers. Cellular and Molecular Life Sciences, 72: 1825-1837.
  • Kuo YC, Wu HT, Hung JJ, Chou TY, Teng SC, Wu KJ. (2015) Nijmegen breakage syndrome protein 1 (NBS1) modulates hypoxia inducible factor-1α (HIF-1α) stability and promotes in vitro migration and invasion under ionizing radiation. Int. J. Biochem. Cell Biol. 64: 229-238.
  • Hung SY, Huang WP, Liou HC, Fu WM. (2015) LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacol., 93: 243-251. (SCI)
  • Hung TM, Yuan RH, HuangWP, Chen YH, Lin YC, Lin CW, Lai HS, Lee PH. (2015) Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. Am. J. Pathol., 185: 2454-2467.
  • Lee SJ, Tsao KC, Cherng BW and Liao YH. Lysophospholipid receptor signaling in zebrafish development. Transl Cancer Res, 2015, 4: 544-556.
  • Wu BT, Wen SH, Hwang SP, Huang CJ and Kuan YS.*. Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression. (2015). J. Cell Sci. 128:2328-2339.
  • Kuan YS, Roberson S, Akitake CM, Fortuno L, Gamse JT, Moens CB, and Halpern ME. (2015). Distinct requirement for Wntless in habenular development. Dev. Biol. 406(2):117-128.
  • Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, Meng TC, Chen GC. (2015) Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation. Oncogene 34: 3791-803.
  • Lee DY and Chang GD.* (2015), Quantitative LC-ESI-MS analysis of amine-containing metabolites derivatized with cyanuric chloride and methylamine isotopologues, J. Chromatography A 1338: 60-68.
  • Yu CH, Chou CC, Lee YJ, Khoo KY, and Chang GD.* (2015) Uncovering Protein Polyamination by the Spermine-specific Antiserum and Mass Spectrometric Analysis, Amino Acids, 47, 469–481
  • Lee, DY and Chang GD*. (2015) Simultaneous Immunoblotting Analysis with Activity Gel Electrophoresis and 2-D Gel Electrophoresis, Methods Mol. Biol. 1312:61-72.
  • Lee, DY and Chang GD*. (2015) Post-staining electroblotting for reliable peptide blotting, Methods Mol. Biol. 1312:185-195.
  • Lin SJ, Lee DY, Wang HC, Kang ST, Hwang PP, Kou GH, Huang MF, Chang GD*, Lo CF*. (2015) White Spot Syndrome Virus Protein Kinase 1 (PK1) Defeats the Host Cell's Iron Withholding Defense Mechanism by Interacting with Host Ferritin. J. Virol. 89, 1083-1093.
  • Klionsky DJ, et al. "Guidelines for the use and interpretation of assays for monitoring autophagy" Autophagy (in press).
  • Hu CW, Hsu CL, Wang YC, Ishihama Y, Ku WC, Huang HC* and Juan HF.* (2015) "Temporal phosphoproteome dynamics induced by an ATP synthase inhibitor citreoviridin" Molecular & Cellular Proteomics 14(12):3284-98.
  • Hsu CL, Juan HF.*, and Huang HC.* (2015) "Characterization and functional analysis of differential coexpression networks" Scientific Reports 5:13295.
  • Jen J, Lin LL, Chen HT, Liao SY, Lo FY, Tang YA, Hsu HS, Salgia R, Hsu CL, Huang HC, Juan HF*, Wang YC.* (2015) "Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer" Oncogene (doi: 10.1038/onc.2015.296).
  • Lin LL, Hsu CL, Hu CW, Ko SY, Hsieh HL, Huang HC*, Juan HF.* (2015) "Integrating phosphoproteomics and bioinformatics to study brassinosteroid-regulated phosphorylation dynamics in Arabidopsis" BMC Genomics 16:533. (Highly accessed)
  • Lin LL, Huang HC*, Juan HF.* (2015) "Circadian systems biology in metazoa" Briefings in Bioinformatics 16(6):1008-24
  • Huang MJ, Hu RH, Chou CH, Hsu CL, Liu YW, Huang J, Hung JS, Lai IR, Juan HF, Yu SL, Wu YM.* and Huang MC.* (2015) "Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling" Oncotarget 6(8):5650-65.
  • Lee AYL*, Chiu YC, Fang WC, Cheng CW, Kuo CY, Juan HF, Wu SH* and Kao TY.* (2015) "Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex" Cell Death & Disease 6:e1642.
  • Lin LL, Hsia CR, Hsu CL, Huang HC* and Juan HF.* (2015) "Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells" BMC Genomics 16(1):41.
  • Chang HY, Li MH, Huang TC, Hsu CL, Tsai SR, Lee SC*, Huang HC* and Juan HF.* (2015) "Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells" Journal of Proteome Research 14(2):1250-62.
  • Chan CC, Fan MY, Wan WH, Lin SJ*. (2015) A two-stepped culture method for efficient production of trichogenic keratinocytes. Tissue Engineering Part C Methods 21:1070-9.
  • Lin YC, Lin MW, Yen MH, Fan SMY, Wu JT, Young TH, Cheng JY, Lin SJ*. (2015) Programmable laser-assisted surface microfabrication on a polyvinyl alcohol-coated glass chip with self-changing cell adhesivity for heterotypic cell patterning. ACS Applied Materials& Interfaces 7:22322-32.
  • Chen KL, Chiu HY, Chan CC, Chan JY, Lin SJ*. Extensive cicatricial alopecia in a patient with long-term trichotillomania. Journal of Dermatology (accepted).
  • Wu YF, Wang SH, Wu PS, Sabrina Fan MY, Chiu HY, Tsai TH, Lin SJ*. (2015) Enhancing hair follicle regeneration by nonablative fractional laser: assessment of irradiation parameters and tissue response. Lasers in Surgery and Medicine 47:331-41.
  • Chiu HY, Wang TS, Chan CC, Lin SJ, Tsai TF. Risk factor analysis for the immunogenicity of adalimumab associated with decreased clinical response in Chinese patients with psoriasis. Acta Dermato-Venereologica 95:71-6, 2015.
  • Sheen YS, Fan SMY, Chan CC, Wu YF, Jee SH, Lin SJ*. Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro. Lasers in Surgery and Medicine 47: 50-9, 2015.
  • Chiu HY, Huang HL, Li CH, Yin YJ, Chen HA, Hsu ST, Lin SJ, Tsai TF, Ho SY. Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study. British Journal of Dermatology 173:146-54, 2015.
  • Oh JW, Lin SJ, Plikus MV. Regenerative metamorphosis in hairs and feathers: follicle as a programmable biological printer. Experimental Dermatology 24:262-4, 2015.
  • Lin KH, Liao BY, Chang HW, Huang SW, Chang TY, Yang CY, Wang YB, Kirk Lin YT, Wu YW, Tang SL and Yu HT Metabolic characteristics of dominant microbes and key rare species from an acidic hot spring in Taiwan revealed by metagenomics. BMC Genomics 2015, 16:1029
  • Wada K, Lee JY, Hung HY, Shi Q, Lin L, Zhao Y, Goto M, Yang PC, Kuo SC, Chen HW*, Lee KH*. Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects. Bioorg Med Chem. 2015 Apr 1;23(7):1507-14.
  • Huang CH, Tsai MS, Chiang CY, Su YJ, Wang TD, Chang WT, Chen HW, Chen WJ. Activation of mitochondrial STAT-3 and reduced mitochondria damage during hypothermia treatment for post-cardiac arrest myocardial dysfunction. Basic Res Cardiol. 2015 Nov;110(6):59.
  • Yuan A, Hsiao YJ, Chen HY, Chen HW, Ho CC, Chen YY, Liu YC, Hong TH, Yu SL, Chen JJ, Yang PC. Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression. Sci Rep. 2015, 5:14273.
  • Lai YH, Chen MH, Lin SY, Lin SY, Wong YH, Yu SL, Chen HW, Yang CH, Chang GC, Chen JJ. Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways. Oncotarget. 2015 Sep 22;6(28):26252-65.
  • Tsai MS, Huang CH, Yu PH, Tsai CY, Chen HW, Cheng HJ, Chang WT, Wang TD, Chen WJ. Prolonged cooling duration mitigates myocardial and cerebral damage in cardiac arrest. Am J Emerg Med. 2015 Oct;33(10):1374-81.
  • Liao HY, Chen JH, Shyue JJ, Shun CT, Chen HW, Liao SW, Hong CK, Chen PS. Rapid label-free determination of ketamine in whole blood using secondary ion mass spectrometry. Talanta. 2015 Oct 1;143:50-5.
  • Chen HY, Yu SL, Ho BC, Su KY, Hsu YC, Chang CS, Li YC, Yang SY, Hsu PY, Ho H, Chang YH, Chen CY, Yang HI, Hsu CP, Yang TY, Chen KC, Hsu KH, Tseng JS, Hsia JY, Chuang CY, Yuan S, Lee MH, Liu CH, Wu GI, Hsiung CA, Chen YM, Wang CL, Huang MS, Yu CJ, Chen KY, Tsai YH, Su WC, Chen HW, Chen JJ, Chen CJ, Chang GC, Yang PC, Li KC. R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability. J Clin Oncol. 2015, 33(20):2303-10.
  • Huang CH, Chiang CY, Pen RH, Tsai MS, Chen HW, Hsu CY, Wang TD, Ma MH, Chen SC, Chen WJ. Hypothermia treatment preserves mitochondrial integrity and viability of cardiomyocytes after ischaemic reperfusion injury. Injury. 2015, 46(2):233-9.
  • Bowman, J.L., Araki, T., Arteaga-Vazquez, M.A., Berger, F., Dolan, L., Haseloff, J., Ishizaki, K., Kyozuka, J., Lin, S.S., Nagasaki, H., Nakagami, H., Nakajima, K., Nakamura, Y., Ohashi-Ito, K., Sawa, S., Shimamura, M., Solano, R., Tsukaya, H., Ueda, T., Watanabe, Y., Yamato, K.T., Zachgo, S., Kohchi, T. 2015. The naming of names: guidelines for gene nomenclature in Marchantia. Plant Cell Physiol. (Accepted)
  • Chen KI, Pan CY, Li KH, Huang YC, Lu CW, Tang CY, Su YW,Tseng LW, Tseng KC, Lin CY, Chen CD, Lin SS*, Chen YT*. 2015. Isolation and identification of post-transcriptional gene silencing-related micro-RNAs by functionalized silicon nanowire field-effect transistor. Sci. Rep. 5, 17375
  • Liu CT, Huang HM, Hong SF, Kuo-Huang LL, Yang CY, Lin YY, Lin CP*, Lin SS.* 2015. Peanut witches’ broom (PnWB) phytoplasma-mediated leafy flower symptoms and abnormal vascular bundles development. Plant Signal Behav. (Accepted)
  • Lee CT, Chen IT, Yang YT, Ko TP, Huang YT, Huang JY, Huang MF, Lin SJ, Chen CY, Lin SS, Lightener DV, Wang HC, Wang AHJ, Wang HC, Hor LI, Lo CF. 2015. The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin. PNAS 112:10798-10803.
  • Liao HF, Mo CF, Wu SC, Cheng DH, Yu CY, Chang KW, Kao TH, Lu CW, Pinskaya M, Morillon A, Lin SS, Cheng WT, Bourc'his D, Bestor T, Sung LY, Lin SP. 2015. Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. Reproduction 150:245-256.
  • Yang CY, Huang YH, Lin CP, Lin YY, Hsu HC, Wang CN, Liu LY, Shen BN, Lin SS.* 2015. MiR396-targeted SHORT VEGETATIVE PHASE is required to repress flowering and is related to the development of abnormal flower symptoms by the Phyllody Symptoms1 effector. Plant Physiol. 168:1702-1716.
  • Hu SF, Huang YH, Lin, C.P., Liu, L.Y.D., Hong, S.F., Yang, C.Y., Lo, H.F., Tseng, T.Y., Chen, W.Y., Lin, S.S.* 2015. Development of a mild viral expression system for gain-of-function study of phytoplasma effector in planta. PLOS ONE. 10:e0130139
  • Huang CH, Hsiao WR, Huang CW, Chen KC, Lin SS, Chen TC, Raja JAJ, Wu HW, Yeh SD. 2015. Two novel motifs of Watermelon silver mottle virus NSs protein are responsible for RNA silencing suppression and pathogenicity. PLOS ONE. 10:e0126161
  • Lin YL, Ma LT, Lee YR, Lin SS, Wang SY, Chang TT, Shaw JF, Li WH, Chu FF. 2015. MicroRNA-like small RNAs prediction in the development of Antrodia cinnamomea. PLOS ONE. 10:e0123245
  • Lin PC, Hu WC, Lee SC, Chen YL, Lee CY, Chen YR, Liu LYD, Chen PY., Lin SS.*, Chang YC.* 2015. Application of an integrated omics approach for identifying host proteins that interact with Odontoglossum ringspot virus capsid protein. Mol. Plant Microbe Interact. 28:711-726
  • Yang HW, He BZ, Ma HJ, Tsaur SC, Ma CY, Wu Y, Ting CT, Zhang YE* (2015) Expression profile and gene age jointly shaped the genome-wide distribution of premature termination codons in Drosophila populations. Molecular Biology and Evolution. 32: 216-228. (IF= 13.649 in 2015)
  • Chen WY, Shih HT, Liu KY, Shih ZS, Chen LK, Tsai TH, Chen MJ, Liu H, Tan BCM, Chen CY, Lee HH, Loppin B, Ait-Ahmed O, Wu JT*(2015) Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. EMBO Reports 16:528-538. (IF= 7.739 in 2015)
  • Sheen YS, Liao YH, Lin MH, Chu CY, Ho BY, Hsieh MC, Chen PC, Cha ST, Jeng YM, Chang CC, Chiu HC, Jee SH, Kuo ML, Chu CY* (2015) IMP-3 promotes tumor invasion and predicts poor prognosis in melanoma by regulating HMGA2 expression. J. Invest. Dermatol. 135(4):1065-1073. (IF= 6.915 in 2015)
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