近期研究成果

Oct, 2022
Hsueh-Ping Chu
Alternative Lengthening of Telomeres (ALT) utilizes a recombination mechanism and break-induced DNA synthesis to maintain telomere length without telomerase, but it is unclear how cells initiate ALT. TERRA, telomeric repeat-containing RNA, forms RNA:DNA hybrids (R-loops) at ALT telomeres. We show that depleting TERRA using an RNA-targeting Cas9 system reduces ALT-associated PML bodies, telomere...
Sep, 2022
Chia-Lang Hsu and Hsueh-Fen Juan
The small nucleolar RNA host gene 1 (SNHG1) is a novel oncogenic long non-coding RNA (lncRNA) aberrantly expressed in different tumor types. We previously found highly expressed SNHG1 was associated with poor prognosis and MYCN status in neuroblastoma (NB). However, the molecular mechanisms of SNHG1 in NB are still unclear. Here, we disrupted endogenous SNHG1 in the MYCN-amplified NB cell line SK...
Sep, 2022
Chia-Lang Hsu and Pei-Lung Chen
Adaptive immune receptor repertoire (AIRR) is encoded by T cell receptor (TR) and immunoglobulin (IG) genes. Profiling these germline genes encoding AIRR (abbreviated as gAIRR) is important in understanding adaptive immune responses but is challenging due to the high genetic complexity. Our gAIRR Suite comprises three modules. gAIRR-seq, a probe capture-based targeted sequencing pipeline,...
Jun, 2022
Hsueh-Fen Juan
The tumor microenvironment (TME), which comprises cellular and noncellular components, is involved in the complex process of cancer development. Emerging evidence suggests that mesenchymal stem cells (MSCs), one of the vital regulators of the TME, foster tumor progression through paracrine secretion. However, the comprehensive phosphosignaling pathways that are mediated by MSC-secreting factors...
May, 2022
Hsueh-Fen Juan and Chien-Yu Chen
With the proliferation of genomic sequence data for biomedical research, the exploration of human genetic information by domain experts requires a comprehensive interrogation of large numbers of scientific publications in PubMed. However, a query in PubMed essentially provides search results sorted only by the date of publication. A search engine for retrieving and interpreting complex relations...
May, 2022
Te-Lun Mai
Circular RNAs (circRNAs) are a class of non-coding RNAs formed by pre-mRNA back-splicing, which are widely expressed in animal/plant cells and often play an important role in regulating microRNA (miRNA) activities. While numerous databases have collected a large amount of predicted circRNA candidates and provided the corresponding circRNA-regulated interactions, a stand-alone package for...
Apr, 2022
Jian-Da Lin
Single-cell transcriptomic data identifies major activation paths of monocyte-derived macrophages as a framework for inflammatory tissue macrophages.
Apr, 2022
Hsueh-Fen Juan
Mitochondria are crucial organelles that provide energy via oxidative phosphorylation in eukaryotic cells and also have critical roles in growth, division, and the cell cycle, as well as the rapid adaptation required to meet the metabolic needs of the cell. Mitochondrial processes are highly dynamic; fusion and fission can vary with cell type, cellular context, and stress levels. Accumulating...
Feb, 2022
Hsueh-Fen Juan
Single-cell RNA sequencing (scRNA-seq) approach can broadly and specifically evaluate the individual cells with minimum detection bias. To explore the individual compositional and transcriptional alteration of intestinal leukocytes in the Dual Specificity Phosphatase six knockout (D6KO) mice, we performed a scRNA-seq followed by the cell type annotation based on ImmGen database. Composition...
Feb, 2022
Hsueh-Fen Juan
The hourglass model is a popular evo-devo model depicting that the developmental constraints in the middle of a developmental process are higher, and hence the phenotypes are evolutionarily more conserved, than those that occur in early and late ontogeny stages. Although this model has been supported by studies analyzing developmental gene expression data, the evolutionary explanation and...

焦點活動

本中心參與協辦「2022多體學及精準醫學聯合會議」,邀請到三位國際專家級學者與多位國內專家學者來進行專題演講與討論,內容精彩可期,歡迎大家踴躍報名參加!

焦點新聞

中心副主任 陳倩瑜教授接受 Nature 旗下知名期刊 Communication Biology 訪談,分享她由一名半導體工程師出身,轉換跑道並成為一名傑出的計算生物學家的心路歷程。陳教授專長為機器學習與人工智慧,並聚焦於多體學相關研究。在訪談中,陳教授除了對計算生物學的發展趨勢,提出她的看法,並針對有志於跨入計算生物學研究的年輕學者給予寶貴的建議。歡迎點擊以下連結觀閱訪談全文:
https://www.nature.com/articles/s42003-022-03080-x

研究成果亮點

[蜜蜂導航]計畫團隊是由生物與工程兩方面的研究人員所組成的跨領域研究群,進行「蜂群衰竭失調症(CCD)」探討,發現蜜蜂的消失是因為農藥不當使用所造成的後果。此研究成果不但廣受國際學術研究重視,並已備受歐盟採納。

相關研究更經由 Discovery 頻道拍攝為影片,於2013年12月全球首播,《台灣無比精彩:尖端農業》於12月30日首播,楊恩誠老師受邀於2014TEDxTaipei演說成果。