近期研究成果
Nov, 2023
PhoSL (Pholiota squarrosa Lectin) has an exceptional binding affinity for biomolecules with core-fucosylated N-glycans. This modification involves the addition of fucose to the inner N-acetylglucosamine within the N-glycan structure and is known to influence many physiological processes. Nevertheless, the molecular interactions underlying high-affinity binding of native PhoSL to core-fucosylated...
Nov, 2023
The immune checkpoint inhibitor (ICI), anti-programmed death-1 (anti-PD-1), has shown moderate efficacy in some patients with head and neck squamous cell carcinoma (HNSCC). Because of this, it is imperative to establish a mouse tumor model to explore mechanisms of antitumor immunity and to develop novel therapeutic options. Here, we examined the 4-nitroquinoline-1-oxide (4NQO)-induced oral...
Oct, 2023
Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness. Recent investigations have uncovered that phosphoglycerate dehydrogenase (PHGDH), an essential enzyme for de novo serine synthesis, serves as a non-oncogene dependency in high-risk...
Sep, 2023
Antrodia cinnamomea is an endemic species found in Taiwan, known for its medicinal properties in treating various discomforts, including inflammation, diarrhea, abdominal pain, and other diseases. A. cinnamomea contains terpenoids that exhibit numerous bioactivities, making them potential food additives. This discovery piqued our interest in uncovering their biosynthetic pathway. Herein, we...
Jun, 2023
Ectopic ATP synthase on the plasma membrane (eATP synthase) has been found in various cancer types and is a potential target for cancer therapy. However, whether it provides a functional role in tumor progression remains unclear. Here, quantitative proteomics reveals that cancer cells under starvation stress express higher eATP synthase and enhance the production of extracellular vesicles (EVs),...
Apr, 2023
Ectopic ATP synthase complex (eATP synthase), located on cancer cell surface, has been reported to possess catalytic activity that facilitates the generation of ATP in the extracellular environment to establish a suitable microenvironment and to be a potential target for cancer therapy. However, the mechanism of intracellular ATP synthase complex transport remains unclear. Using a combination of...
Feb, 2023
The study of multiple “omes,” such as the genome, transcriptome, proteome, and metabolome has become widespread in biomedical research. High-throughput techniques enable the rapid generation of high-dimensional multiomics data. This multiomics approach provides a more complete perspective to study biological systems compared with traditional methods. However, the quantitative analysis and...
Jan, 2023
Background: Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with various metaplastic components. Although previous transcriptomic and proteomic studies have reported subtype-related heterogeneity, the intracase transcriptomic alterations between metaplastic components and paired NST components, which are critical for understanding the pathogenesis...
Jan, 2023
The study of multiple “omes,” such as the genome, transcriptome, proteome, and metabolome has become widespread in biomedical research. High-throughput techniques enable the rapid generation of high-dimensional multiomics data. This multiomics approach provides a more complete perspective to study biological systems compared with traditional methods. However, the quantitative analysis and...
Jan, 2023
Xylem, the most abundant tissue on Earth, is responsible for lateral growth in plants. Typical xylem has a radial system composed of ray parenchyma cells and an axial system of fusiform cells. In most angiosperms, fusiform cells comprise vessel elements for water transportation and libriform fibers for mechanical support, while both functions are performed by tracheids in other vascular plants...
焦點活動
焦點新聞
2024 SMBE臺灣區域會議：演化基因體與生物資訊學 圓滿落幕
臺大計算與系統生物學研究中心與臺灣演化與計算生物學會首次在臺灣舉辦的 「2024 SMBE臺灣區域會議：演化基因體與生物資訊學｣ 圓滿落幕，提高臺灣在演化基因體與生物資訊學的國際聲望。
歡迎點擊連結觀閱全文：NTU e-Newsletter
中心副主任 陳倩瑜教授接受 Nature 旗下知名期刊 Communication Biology 訪談，分享她由一名半導體工程師出身，轉換跑道並成為一名傑出的計算生物學家的心路歷程。陳教授專長為機器學習與人工智慧，並聚焦於多體學相關研究。在訪談中，陳教授除了對計算生物學的發展趨勢，提出她的看法，並針對有志於跨入計算生物學研究的年輕學者給予寶貴的建議。歡迎點擊以下連結觀閱訪談全文：
https://www.nature.com/articles/s42003-022-03080-x
中心公告
2022-07-12 阮雪芬老師研究室誠徵博士後研究員
2022-01-24 2022年寒假高中生生物資訊營第二梯次與第三梯次停辦。
2021-12-01 2022年寒假高中生生物資訊營，報名延長至12月23日，欲參加者請儘速報名
2021-11-27 生命科學系－系統生物學領域專長說明會報名開放中，歡迎踴躍參加
近期活動
2024-04-08 【Workshop】2024/04/24 IPA workshop
研究成果亮點
[蜜蜂導航]計畫團隊是由生物與工程兩方面的研究人員所組成的跨領域研究群，進行「蜂群衰竭失調症(CCD)」探討，發現蜜蜂的消失是因為農藥不當使用所造成的後果。此研究成果不但廣受國際學術研究重視，並已備受歐盟採納。
相關研究更經由 Discovery 頻道拍攝為影片，於2013年12月全球首播，《台灣無比精彩：尖端農業》於12月30日首播，楊恩誠老師受邀於2014TEDxTaipei演說成果。