近期研究成果

Oct, 2021
Hsueh-Fen Juan and Chien-Yu Chen
The selection of peptides presented by MHC molecules is crucial for antigen discovery. Previously, several predictors have shown impressive performance on binding affinity. However, the decisive MHC residues and their relation to the selection of binding peptides are still unrevealed. Here, we connected HLA alleles with binding motifs via our deep learning-based framework, MHCfovea. MHCfovea...
Oct, 2021
Chun-Hua Hsu
Microbial urate oxidase has emerged as a potential source of therapeutic properties for hyperuricemia in arthritic gout and renal disease. The thermostability and long-term thermal tolerance of the enzyme need to be established to prolong its therapeutic effects. Here, we present the biochemical and structural aspects of a hyperthermostable urate oxidase (TbUox) from the thermophilic...
Aug, 2021
Chun-Hua Hsu
O-Acetyl-ADP-ribose (OAADPR) is a signaling molecule identified from the conserved sirtuin reaction in Saccharomyces cerevisiae, involved in the important cellular functions of gene silencing, redox regulation, and aging. Here, we performed biochemical and structural characterization of the yeast Poa1p macro domain in detail, uncovering an unusual deacetylase activity favoring 3″- and 1″-isomers...
Jul, 2021
Hsueh-Fen Juan
LncTx is a network-based method to repurpose drugs that potentially act on lncRNAs in lung cancer. By calculating the proximity between the drug targets and the lncRNA-correlated proteins in the protein-protein interaction (PPI) network, LncTx accurately differentiates anticancer drugs from non-anticancer drugs. Furthermore, the drugs with smaller proximity (proximal drugs) are more effective...
May, 2021
Chia-Lang Hsu
Reversal of CD8 T-cell exhaustion was considered a major antitumor mechanism of anti-programmed cell death-1 (PD-1)/ anti-programmed death ligand-1 (PD-L1)-based immune checkpoint inhibitor (ICI) therapy. The aim of this study was to identify markers of T-cell exhaustion that is best associated with ICI treatment efficacy for advanced hepatocellular carcinoma (HCC). Here, we identified a 9-gene...
May, 2021
Chia-Lang Hsu and Shau-Ping Lin
Sophisticated axolotl limb regeneration is a highly orchestrated process that requires highly regulated gene expression and epigenetic modification patterns at precise positions and timings. We previously demonstrated two waves of post-amputation expression of a nerve-mediated repressive epigenetic modulator, histone deacetylase 1 (HDAC1), at the wound healing (3 days post-amputation; 3 dpa) and...
Jan, 2021
Chun-Hua Hsu
The macro domain is an ADP-ribose (ADPR) binding module, which is considered to act as a sensor to recognize nicotinamide adenine dinucleotide (NAD) metabolites, including poly ADPR (PAR) and other small molecules. The recognition of macro domains with various ligands is important for a variety of biological functions involved in NAD metabolism, including DNA repair, chromatin remodeling,...
Jan, 2021
Hsin-Hung David Chou
Whole-cell biosensors are useful for monitoring heavy metal toxicity in public health and ecosystems, but their development has been hindered by intrinsic trade-offs between sensitivity and specificity. Here we demonstrated an effective engineering solution by building a sensitive, specific, and high-response biosensor for carcinogenic cadmium ions. We genetically programmed the metal transport...
Jan, 2021
Chien-Yu Chen and Hsueh-Fen Juan
The current state of the COVID-19 pandemic is a global health crisis. To fight the novel coronavirus, one of the best-known ways is to block enzymes essential for virus replication. Currently, we know that the SARS-CoV-2 virus encodes about 29 proteins such as spike protein, 3C-like protease (3CLpro), RNA-dependent RNA polymerase (RdRp), Papain-like protease (PLpro), and nucleocapsid (N) protein...
Sep, 2020
Chun-Hua Hsu
The pandemic outbreak of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has threatened the global public health and economy since late December 2019. SARS-CoV-2 encodes the conserved macro domain within nonstructural protein 3, which may reverse cellular ADP-ribosylation and potentially cut the signal of a viral infection in the cell. Herein, we report that the...

研究成果亮點

[蜜蜂導航]計畫團隊是由生物與工程兩方面的研究人員所組成的跨領域研究群,進行「蜂群衰竭失調症(CCD)」探討,發現蜜蜂的消失是因為農藥不當使用所造成的後果。此研究成果不但廣受國際學術研究重視,並已備受歐盟採納。

相關研究更經由 Discovery 頻道拍攝為影片,於2013年12月全球首播,《台灣無比精彩:尖端農業》於12月30日首播,楊恩誠老師受邀於2014TEDxTaipei演說成果。