近期研究成果

Apr, 2022
Jian-Da Lin
Single-cell transcriptomic data identifies major activation paths of monocyte-derived macrophages as a framework for inflammatory tissue macrophages.
Apr, 2022
Hsueh-Fen Juan
Mitochondria are crucial organelles that provide energy via oxidative phosphorylation in eukaryotic cells and also have critical roles in growth, division, and the cell cycle, as well as the rapid adaptation required to meet the metabolic needs of the cell. Mitochondrial processes are highly dynamic; fusion and fission can vary with cell type, cellular context, and stress levels. Accumulating...
Feb, 2022
Hsueh-Fen Juan
Single-cell RNA sequencing (scRNA-seq) approach can broadly and specifically evaluate the individual cells with minimum detection bias. To explore the individual compositional and transcriptional alteration of intestinal leukocytes in the Dual Specificity Phosphatase six knockout (D6KO) mice, we performed a scRNA-seq followed by the cell type annotation based on ImmGen database. Composition...
Feb, 2022
Hsueh-Fen Juan
The hourglass model is a popular evo-devo model depicting that the developmental constraints in the middle of a developmental process are higher, and hence the phenotypes are evolutionarily more conserved, than those that occur in early and late ontogeny stages. Although this model has been supported by studies analyzing developmental gene expression data, the evolutionary explanation and...
Nov, 2021
Hsueh-Fen Juan
Strengthening the gut epithelial barrier is a potential strategy for management of gut microbiota-associated illnesses. Here, we demonstrate that dual-specificity phosphatase 6 (Dusp6) knockout enhances baseline colon barrier integrity and ameliorates dextran sulfate sodium (DSS)-induced colonic injury. DUSP6 mutation in Caco-2 cells enhances the epithelial feature and increases mitochondrial...
Oct, 2021
Hsueh-Fen Juan and Chien-Yu Chen
The selection of peptides presented by MHC molecules is crucial for antigen discovery. Previously, several predictors have shown impressive performance on binding affinity. However, the decisive MHC residues and their relation to the selection of binding peptides are still unrevealed. Here, we connected HLA alleles with binding motifs via our deep learning-based framework, MHCfovea. MHCfovea...
Oct, 2021
Chun-Hua Hsu
Microbial urate oxidase has emerged as a potential source of therapeutic properties for hyperuricemia in arthritic gout and renal disease. The thermostability and long-term thermal tolerance of the enzyme need to be established to prolong its therapeutic effects. Here, we present the biochemical and structural aspects of a hyperthermostable urate oxidase (TbUox) from the thermophilic...
Aug, 2021
Chun-Hua Hsu
O-Acetyl-ADP-ribose (OAADPR) is a signaling molecule identified from the conserved sirtuin reaction in Saccharomyces cerevisiae, involved in the important cellular functions of gene silencing, redox regulation, and aging. Here, we performed biochemical and structural characterization of the yeast Poa1p macro domain in detail, uncovering an unusual deacetylase activity favoring 3″- and 1″-isomers...
Jul, 2021
Hsueh-Fen Juan
LncTx is a network-based method to repurpose drugs that potentially act on lncRNAs in lung cancer. By calculating the proximity between the drug targets and the lncRNA-correlated proteins in the protein-protein interaction (PPI) network, LncTx accurately differentiates anticancer drugs from non-anticancer drugs. Furthermore, the drugs with smaller proximity (proximal drugs) are more effective...
May, 2021
Chia-Lang Hsu
Reversal of CD8 T-cell exhaustion was considered a major antitumor mechanism of anti-programmed cell death-1 (PD-1)/ anti-programmed death ligand-1 (PD-L1)-based immune checkpoint inhibitor (ICI) therapy. The aim of this study was to identify markers of T-cell exhaustion that is best associated with ICI treatment efficacy for advanced hepatocellular carcinoma (HCC). Here, we identified a 9-gene...

焦點活動

本中心與臺大生化科技系特別邀請到臺灣台灣人工智慧實驗室(Taiwan AI Labs)創辦人─杜奕瑾發表演講,歡迎大家踴躍參加!

焦點新聞

中心副主任 陳倩瑜教授接受 Nature 旗下知名期刊 Communication Biology 訪談,分享她由一名半導體工程師出身,轉換跑道並成為一名傑出的計算生物學家的心路歷程。陳教授專長為機器學習與人工智慧,並聚焦於多體學相關研究。在訪談中,陳教授除了對計算生物學的發展趨勢,提出她的看法,並針對有志於跨入計算生物學研究的年輕學者給予寶貴的建議。歡迎點擊以下連結觀閱訪談全文:
https://www.nature.com/articles/s42003-022-03080-x

研究成果亮點

[蜜蜂導航]計畫團隊是由生物與工程兩方面的研究人員所組成的跨領域研究群,進行「蜂群衰竭失調症(CCD)」探討,發現蜜蜂的消失是因為農藥不當使用所造成的後果。此研究成果不但廣受國際學術研究重視,並已備受歐盟採納。

相關研究更經由 Discovery 頻道拍攝為影片,於2013年12月全球首播,《台灣無比精彩:尖端農業》於12月30日首播,楊恩誠老師受邀於2014TEDxTaipei演說成果。