近期研究成果

Jun, 2024
Tzu-Pin Lu
Purpose: This study aims to raise awareness of the disparities in survival predictions among races in head and neck cancer (HNC) patients by developing and validating population-based prognostic models specifically tailored for Taiwanese and Asian populations. Methods: A total of 49,137 patients diagnosed with HNCs were included from the Taiwan Cancer Registry (TCR). Six prognostic models,...
May, 2024
Pei-Lung Chen and Shu-Jui Hsu
"Background: To identify genotypes associated with neovascular age-related macular degeneration (nAMD) and investigate the associations between genotype variations and anti-vascular endothelial growth factor (VEGF) treatment response. Methods: This observational, retrospective, case series study enrolled patients diagnosed with nAMD who received anti-VEGF treatment in National Taiwan...
May, 2024
Te-Lun Mai and Ying-Chung Lin
Phenotypic drug discovery (PDD) is an effective drug discovery approach by observation of therapeutic effects on disease phenotypes, especially in complex disease systems. Triple-negative breast cancer (TNBC) is composed of several complex disease features, including high tumor heterogeneity, high invasive and metastatic potential, and a lack of effective therapeutic targets. Therefore,...
Apr, 2024
Ying-Chung Lin
Cell type annotation and lineage construction are two of the most critical tasks conducted in the analyses of single-cell RNA sequencing (scRNA-seq). Four recent scRNA-seq studies of differentiating xylem propose four models on differentiating xylem development in Populus. The differences are mostly caused by the use of different strategies for cell type annotation and subsequent lineage...
Apr, 2024
Shu-Jui Hsu, Chien-Yu Chen and Pei-Lung Chen
Human leukocyte antigen (HLA) genes play pivotal roles in numerous immunological applications. Given the immense number of polymorphisms, achieving accurate high-throughput HLA typing remains challenging. This study aimed to harness the human pan-genome reference consortium (HPRC) resources as a potential benchmark for HLA reference materials. We meticulously annotated specific four field-...
Mar, 2024
Chun-Hua Hsu
Toxoplasmosis, caused by Toxoplasma gondii, poses risks to vulnerable populations. TgPDCD5, a secreted protein of T. gondii, induces apoptosis through heparan sulfate-mediated endocytosis. The entry mechanism of TgPDCD5 has remained elusive. Here, we present the solution structure of TgPDCD5 as a helical bundle with an extended N-terminal helix, exhibiting molten globule characteristics. NMR...
Mar, 2024
Shau-Ping Lin
In this paper, we explore the challenges associated with biomarker identification for diagnosis purpose in biomedical experiments, and propose a novel approach to handle the above challenging scenario via the generalization of the Dantzig selector. To improve the efficiency of the regularization method, we introduce a transformation from an inherent nonlinear programming due to its nonlinear link...
Feb, 2024
Tzu-Pin Lu
Purpose: The purpose of this study is to find essential risk factors associated with liver function (LF) deteriorations within fluctuating long-term LF and their time-varying effects in patients with hepatocellular carcinoma (HCC) receiving hepatic radiotherapy and to identify high-risk groups for adverse LF deteriorations and their changes over time in facilitating the prevention of hepatic...
Jan, 2024
An-Chi Wei
The effects of coronavirus disease 2019 (COVID-19) primarily concern the respiratory tract and lungs; however, studies have shown that all organs are susceptible to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 may involve multiorgan damage from direct viral invasion through angiotensin-converting enzyme 2 (ACE2), through inflammatory cytokine storms, or...
Jan, 2024
Shau-Ping Lin
Introduction: The Swarm Intelligence Based (SIB) method has widely been applied to efficient optimization in many fields with discrete solution domains. E-commerce raises the importance of designing suitable selling strategies, including channel- and direct sales, and the mix of them, but researchers in this field seldom employ advanced metaheuristic techniques in their optimization problem due...

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2024 SMBE臺灣區域會議:演化基因體與生物資訊學 圓滿落幕

臺大計算與系統生物學研究中心與臺灣演化與計算生物學會首次在臺灣舉辦的 「2024 SMBE臺灣區域會議:演化基因體與生物資訊學」 圓滿落幕,提高臺灣在演化基因體與生物資訊學的國際聲望。

歡迎點擊連結觀閱全文:NTU e-Newsletter

 

 

中心副主任 陳倩瑜教授接受 Nature 旗下知名期刊 Communication Biology 訪談,分享她由一名半導體工程師出身,轉換跑道並成為一名傑出的計算生物學家的心路歷程。陳教授專長為機器學習與人工智慧,並聚焦於多體學相關研究。在訪談中,陳教授除了對計算生物學的發展趨勢,提出她的看法,並針對有志於跨入計算生物學研究的年輕學者給予寶貴的建議。歡迎點擊以下連結觀閱訪談全文:
https://www.nature.com/articles/s42003-022-03080-x

研究成果亮點

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