LncTx: A network-based method to repurpose drugs acting on the survival-related lncRNAs in lung cancer

LncTx is a network-based method to repurpose drugs that potentially act on lncRNAs in lung cancer. By calculating the proximity between the drug targets and the lncRNA-correlated proteins in the protein-protein interaction (PPI) network, LncTx accurately differentiates anticancer drugs from non-anticancer drugs. Furthermore, the drugs with smaller proximity (proximal drugs) are more effective than the distal drugs. This novel method provides a framework to repurpose old drugs acting on lncRNAs in lung cancer.