近期研究成果

Jul, 2025
Chun-Hua Hsu and Hsueh-Fen Juan
Neuroblastoma is the most common heterogeneous solid tumor in children, and current treatment options remain limited, especially for high-risk patients. Previous studies have identified dihydroorotate dehydrogenase (DHODH), a key enzyme in pyrimidine synthesis, as a potential therapeutic target in cancer. However, none of the existing FDA-approved DHODH inhibitors have shown effective inhibition...
Jul, 2025
Hsueh-Fen Juan
Neuroblastoma, a prevalent and aggressive childhood cancer, lacks effective treatments. Recent research highlights the repurposing of existing drugs as a strategy for breakthroughs in combating this disease. We systematically analyzed small-molecule perturbation gene expression data from the Library of Integrated Network-Based Cellular Signatures (LINCS), identifying pyrvinium pamoate and...
Apr, 2025
Hsueh-Fen Juan
Breast cancer stands as one of the most prevalent malignancies affecting women. Alterations in molecular pathways in cancer cells represent key regulatory disruptions that drive malignancy, influencing cancer cell survival, proliferation, and potentially modulating therapeutic responsiveness. Therefore, decoding the intricate molecular mechanisms and identifying novel therapeutic targets through...
Apr, 2025
Hsueh-Fen Juan
Neuroblastoma is an aggressive childhood cancer that arises from the sympathetic nervous system. Despite advances in treatment, high-risk neuroblastoma remains difficult to manage due to its heterogeneous nature and frequent development of drug resistance. Drug repurposing guided by single-cell analysis presents a promising strategy for identifying new therapeutic options. Here, we aim to...
Feb, 2025
Chia-Lang Hsu
Lung cancer is the most common cause of cancer mortality globally, and the prevalence of lung adenocarcinoma, the most common lung cancer subtype, has increased sharply in East Asia. Early diagnosis leads to better survival rates, but this requires an improved understanding of the molecular changes during early tumorigenesis, particularly in nonsmokers. In this study, we performed whole-exome...
Jan, 2025
Chun-Hua Hsu
Poly((R)-3-hydroxybutyrate) (PHB) is a microbial biopolymer widely used in commercial biodegradable plastics. PHB degradation in cell is catalyzed by PHB depolymerase (PhaZ), which hydrolyzes the polyester into mono- and/or oligomeric (R)-3-hydroxylbutyrates (3HB). A novel intracellular PhaZ from Bacillus thuringiensis (BtPhaZ) was identified for potential applications in polymer biodegradation...
Dec, 2024
Tzu-Pin Lu
Objective: The aim of this study was to evaluate the efficacy of different treatment intensities (TIs) in patients with nasopharyngeal carcinoma (NPC). Methods: The study assessed newly diagnosed, non-metastatic NPC patients from the Taiwan Cancer Registry between 2010 and 2017. TIs were divided into four groups: TI1 [radiotherapy (RT) alone or induction chemotherapy (IC) followed by RT); TI2 (...
Dec, 2024
Shu-Jui Hsu, Chien-Yu Chen and Pei-Lung Chen
Introduction: The population of Taiwan has a long history of ethno-cultural evolution. The Taiwanese population was isolated from other large populations such as the European, Han Chinese, and Japanese population. The Taiwan Biobank (TWB) project has built a nationwide database, particularly for personal whole-genome sequence (WGS) to facilitate basic and clinical collaboration nationally and...
Oct, 2024
Che Lin
Cancer prognosis requires precision to identify high-risk patients and improve survival outcomes. Conventional methods struggle with the complexity of genetic biomarkers and diverse medical data. Our study uses deep learning to distil high-dimensional medical data into low-dimensional feature vectors exploring shared patterns across cancer types. We developed a multi-task bimodal neural network...
Oct, 2024
Tzu-Pin Lu
Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset...
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阮雪芬主任榮獲「113年度國科會傑出研究獎」

 

CSB Faculty Drive Innovation in Nature Portfolio’s Communications Biology

臺大計算與系統生物學研究中心副主任 陳倩瑜教授 與中心成員 黃韻如教授 &  林建達助理教授 擔任 Editorial Board Members for Communications Biology 榮登 NTU BEATS。

歡迎點擊連結觀閱全文：::: NTU BEATS :::

 

中心副主任 陳倩瑜教授接受 Nature 旗下知名期刊 Communication Biology 訪談，分享她由一名半導體工程師出身，轉換跑道並成為一名傑出的計算生物學家的心路歷程。陳教授專長為機器學習與人工智慧，並聚焦於多體學相關研究。在訪談中，陳教授除了對計算生物學的發展趨勢，提出她的看法，並針對有志於跨入計算生物學研究的年輕學者給予寶貴的建議。歡迎點擊以下連結觀閱訪談全文：
https://www.nature.com/articles/s42003-022-03080-x

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