近期研究成果

Oct, 2025
Te-Lun Mai and Ying-Chung Lin
Secondary growth is a key characteristic evolved from seed plants and generates secondary xylem-the most abundant tissue on Earth. Recent studies have uncovered xylem developmental lineages in eudicots and magnoliids of angiosperms. However, xylem development in gymnosperms, the other representative clade of seed plants, remained elusive. We performed single-cell transcriptomics for xylem cells...
Oct, 2025
Yun-Ju Huang
Epithelial-mesenchymal transition (EMT) is a fundamental mechanism involved in the morphogenesis of metazoans. Through this evolutionarily conserved multi-stage process, cells acquire quasi-epithelial to multiple intermediate morphologies with epithelial and mesenchymal attributes, rarely reaching a complete mesenchymal phenotype. Complex evolutionary-conserved morphogenetic movements in...
Aug, 2025
Pei-Lung Chen and Chien-Yu Chen
Background and aims: Germline genetic factors influence the clinical features of colorectal cancer (CRC); however, these factors remain underexplored in Taiwan. This study aims to evaluate the pathogenicity of germline variants and investigate their associations with familial risk and early-onset CRC. Methods: Whole-exome sequencing of 600 Taiwanese CRC patients was analyzed, assessing variant...
Jul, 2025
Chun-Hua Hsu and Hsueh-Fen Juan
Neuroblastoma is the most common heterogeneous solid tumor in children, and current treatment options remain limited, especially for high-risk patients. Previous studies have identified dihydroorotate dehydrogenase (DHODH), a key enzyme in pyrimidine synthesis, as a potential therapeutic target in cancer. However, none of the existing FDA-approved DHODH inhibitors have shown effective inhibition...
Jul, 2025
Hsueh-Ping Chu
Telomeric repeat-containing RNA (TERRA), transcribed from subtelomeric regions toward telomeric ends, poses challenges in deciphering its complete sequences. Utilizing TERRA-capture RNA-seq and Oxford Nanopore direct RNA sequencing to acquire full-length TERRA, we annotate TERRA transcription regions in the human T2T-CHM13 reference genome. TERRA transcripts encompass hundreds to over a thousand...
Jul, 2025
Hsueh-Fen Juan
Neuroblastoma, a prevalent and aggressive childhood cancer, lacks effective treatments. Recent research highlights the repurposing of existing drugs as a strategy for breakthroughs in combating this disease. We systematically analyzed small-molecule perturbation gene expression data from the Library of Integrated Network-Based Cellular Signatures (LINCS), identifying pyrvinium pamoate and...
Jul, 2025
An-Chi Wei
Doxorubicin (DOX), although effective in treating cancer, has significant cardiac side effects, which limit its clinical utility. In this study, we collected time-course transcriptomics and metabolomics data from the human cardiomyocyte cell line AC16, which we analyzed along with curated public transcriptomics data on DOX-induced toxicity. We developed a multiomics analysis workflow and a...
Jun, 2025
Chien-Yu Chen, Pei-Lung Chen and Shu-Jui Hsu
Background: High-throughput sequencing has revolutionized genetic disorder diagnosis, but variant pathogenicity interpretation is still challenging. Even though the human genome variation society (HGVS) provides recommendations for variant nomenclature, discrepancies in annotation remain a significant hurdle. Results: In this study, we evaluated the annotation concordance between three tools-...
Jun, 2025
Pei-Lung Chen, Chien-Yu Chen and Shu-Jui Hsu
Evaluating robustness of somatic mutation detections is essential when using whole-exome sequencing (WES) for treatment decision-making. A comprehensive evaluation was conducted using tumor WES from the US Food and Drug Administration-led Sequencing Quality Control Phase 2 project, in which multiple library kits sequenced identical DNA materials across three laboratories to benchmark analytical...
May, 2025
Chia-Lang Hsu
Background and objectives: Coffee intake is linked to a reduced risk of Parkinson disease (PD), but whether this effect is mediated by gut microbiota and metabolomic changes remains unclear. This study examines PD-associated metabolomic shifts, caffeine metabolism, and their connection to gut microbiome alterations in a multicenter study. Methods: We conducted an untargeted serum metabolomic...
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阮雪芬主任榮獲「113年度國科會傑出研究獎」

 

CSB Faculty Drive Innovation in Nature Portfolio’s Communications Biology

臺大計算與系統生物學研究中心副主任 陳倩瑜教授 與中心成員 黃韻如教授 &  林建達助理教授 擔任 Editorial Board Members for Communications Biology 榮登 NTU BEATS。

歡迎點擊連結觀閱全文：::: NTU BEATS :::

 

中心副主任 陳倩瑜教授接受 Nature 旗下知名期刊 Communication Biology 訪談，分享她由一名半導體工程師出身，轉換跑道並成為一名傑出的計算生物學家的心路歷程。陳教授專長為機器學習與人工智慧，並聚焦於多體學相關研究。在訪談中，陳教授除了對計算生物學的發展趨勢，提出她的看法，並針對有志於跨入計算生物學研究的年輕學者給予寶貴的建議。歡迎點擊以下連結觀閱訪談全文：
https://www.nature.com/articles/s42003-022-03080-x

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